Why is monitoring kidney function important when prescribing Digoxin?

Monitoring kidney function when prescribing Digoxin is crucial primarily because it ensures effective drug clearance and helps avoid toxicity. Digoxin is primarily excreted by the kidneys, and impaired renal function can lead to the accumulation of the drug in the body. Elevated levels of Digoxin increase the risk for toxicity, which can result in severe adverse effects, including nausea, vomiting, confusion, and life-threatening arrhythmias.

When kidney function declines, the body’s ability to filter and remove Digoxin is compromised, making regular assessment of renal function essential to adjust the dosage appropriately and maintain therapeutic levels. This practice helps in optimizing treatment while minimizing the risks associated with Digoxin use, particularly in geriatric patients who often have comorbid conditions that affect kidney function.