In which conditions is Metformin contraindicated?

Metformin is contraindicated in renal failure due to the risk of lactic acidosis, a serious condition that can occur when the drug accumulates in the body because the kidneys are unable to eliminate it effectively. Since Metformin is primarily excreted through the kidneys, any impairment in renal function can lead to increased levels of the medication, raising the likelihood of adverse effects and further complications.

Knowing this, healthcare providers avoid prescribing Metformin for patients with renal failure to ensure their safety and prevent potentially life-threatening situations. The other conditions listed, while serious, do not directly affect the pharmacokinetics of Metformin in the same way as renal dysfunction does.